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 Welcome to Trials

Do we want more cancer patients on clinical trials?

The key metric is not the number of patients on clinical trials, but the number on the sort of trials that can be used as a basis for clinical decisions, explains Trials Associate Editor, Andrew J Vickers in his latest commentary. Financial and regulatory barriers to greater clinical participation are also discussed.

See related research article by Wright et al., http://www.trialsjournal.com/content/9/1/12


Research    
A review of RCTs in four medical journals to assess the use of imputation to overcome missing data in quality of life outcomes
Shona Fielding, Graeme Maclennan, Jonathan A Cook, Craig R Ramsay
Trials 2008, 9:51 (11 August 2008)
[Abstract] [Provisional PDF] [PubMed] [Related articles]




Study protocol    
A pragmatic cluster randomised controlled trial to evaluate the safety, clinical effectiveness, cost effectiveness and satisfaction with point of care testing in a general practice setting - rationale, design and baseline characteristics
Caroline Laurence, Angela Gialamas, Lisa Yelland, Tanya Bubner, Philip Ryan, Kristyn Willson, Briony Glastonbury, Janice Gill, Mark Shephard, Justin Beilby, PoCT Trial Management Committee
Trials 2008, 9:50 (6 August 2008)
[Abstract] [Provisional PDF] [PubMed] [Related articles]




Study protocol    
Non-invasive cardiac assessment in high risk patients (the ground study): Rationale, objectives and design of a multi-center randomized controlled clinical trial
Alexander M de Vos, Annemarieke Rutten, Hester J van der Zaag-Loonen, Michiel L Bots, Riksta Dikkers, Robert A Buiskool, Willem P Mali, Daniel D Lubbers, Arend Mosterd, Mathias Prokop, Benno J Rensing, Maarten J Cramer, H WOUTER van Es, Frans L Moll, Eric D van de Pavoordt, Pieter A Doevendans, Birgitta K Velthuis, Albert J Mackaay, Felix Zijlstra, Matthijs Oudkerk
Trials 2008, 9:49 (1 August 2008)
[Abstract] [Provisional PDF] [PubMed] [Related articles]




Study protocol    
Bright light in elderly subjects with nonseasonal major depression: a double blind, randomised clinical trial using early morning bright blue light comparing dim red light treatment
Ritsaert Lieverse, Marjan M.A. Nielen, Dick J Veltman, Bernard Uitdehaag, Eus J.W. van Someren, Jan H. Smit, Witte J.G. Hoogendijk
Trials 2008, 9:48 (31 July 2008)
[Abstract] [Provisional PDF] [PubMed] [Related articles]




Research    
Meta-analysis of trials comparing anastrozole and tamoxifen for adjuvant treatment of postmenopausal women with early breast cancer
Adnan Aydiner, Faruk Tas
Trials 2008, 9:47 (29 July 2008)
[Abstract] [Full Text] [PDF] [PubMed] [Related articles]






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 ISSN: 1745-6215

Trials was formerly published as Current Controlled Trials in Cardiovascular Medicine [more info].



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